British Airways will deploy an A380 on its London Heathrow to Singapore route from 28 October.
The service will initially operate three-times weekly, with outbound flights departing on Tuesdays, Thursdays and Saturdays, and each return leg taking-off the following day.
From February 2015, BA will upgrade the service to daily, adding 4,000 seats a month to the route.
Flight BA11 will depart LHR at 19:20 and arrive in Singapore the following day at 15:55, while return service BA12 will leave Singapore at 23:10 and land at Heathrow at 04:50 the next morning.
Other flights on the route - including BA15/BA16, which continues beyond Singapore to Sydney - will continue as before.
The airline currently operates its A380s to Hong Kong, Los Angeles and Johannesburg, and will deploy the aircraft on its London-Washington DC route from September 2014.