Eastern Airways is to launch a daily (except Saturday) service between Southampton and Brussels on 16 April.
The regional carrier will fill the gap left by the withdrawal of Flybe from the route in February.
Weekday flights will leave Southampton Airport at 11:10 on Mondays and Tuesdays, 13:00 on Wednesdays, and 10:55 on Thursdays and Fridays.
From Brussels weekday flights depart at 13:55 on Mondays and Tuesdays, 15:45 on Wednesdays and 13:40 on Thursdays and Fridays (all are local times).
On Sundays services will take off from Southampton at 16:55 and return services depart from Brussels at 19:30.
The news marks the return of Eastern Airways to the route, having previously operated flights until April 2008 when Flybe commenced flights.